MC4R and PDIA6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		MC4R	PDIA6
Description		melanocortin 4 receptor	protein disulfide isomerase family A member 6
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding	Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity
	Biological Process	Diet Induced Thermogenesis Energy Reserve Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Regulation Of Metabolic Process Positive Regulation Of Bone Resorption Regulation Of Eating Behavior Response To Melanocyte-stimulating Hormone Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior	Protein Folding
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Bremelanotide Setmelanotide
Diseases
GWAS		Adult body size ( 32376654) Antipsychotic drug-induced weight gain ( 22566560) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 28552196 29381148 24064335 23563607 26426971 19079260 19079261 26961502 24348519 23669352 24861553 18454148 31453325 28892062 25673413 20935630 29273807 28448500 25953783) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Childhood body mass index ( 33045005 26604143) Childhood onset type 2 diabetes ( 33479058) Cobalt levels ( 26025379) Coffee consumption ( 31046077) Coffee consumption (cups per day) ( 31837886) Coronary artery disease ( 26343387 33020668) Daytime sleep phenotypes ( 27126917) Dentures ( 31235808) Diastolic blood pressure ( 27841878) Fat body mass ( 24064335) Fatty acid desaturase activity (serum) ( 30453627) Femoral neck bone mineral density ( 30172743) Free thyroxine concentration ( 30367059) Fruit consumption ( 32066663) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference ( 28552196 31453325 25673412) Hip circumference variance ( 31453325) Leg fat mass and leg lean mass (pleiotropy) ( 32719433) Leg lean mass (fat adjusted) ( 32719433) Metabolic syndrome ( 31589552) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 23563607 19151714) Obesity (early onset extreme) ( 20421936 23563609) Obesity (extreme) ( 30677029) Obesity-related traits ( 22013104) Systolic blood pressure ( 30224653) Total body bone mineral density ( 30172743) Triglyceride levels ( 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 22885922 24509480 30054458 30297969 32499647 30718926 28869590) Ulna and radius bone mineral density ( 30172743) Urate levels ( 31578528 23263486) Waist circumference ( 28552196 19557197 31453325 25673412) Waist circumference and related phenotypes ( 18454146) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Weight ( 19079260)	Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		20 interacting genes: AGRP AIG1 ASIP ATP6V0E2 ATRNL1 CD81 GRK2 IL1RAP MAL MC1R NPC1 NPY PDIA6 PLLP POMC PRKACA TMEM19 TMEM94 TSPAN3 YIPF3	21 interacting genes: ATP13A2 CASP8 CEP250 CLN8 CSNK2A1 GET3 LGALS9 LINC01554 MC4R MTNR1A MTNR1B NPC2 OGT SGTB SLC22A2 SLC2A4 SUMO4 THAP1 TRIM14 UBE3A VKORC1
Entrez ID		4160	10130
HPRD ID		01116	07504
Ensembl ID		ENSG00000166603	ENSG00000143870
Uniprot IDs		P32245	A0A384NPU5 Q15084
PDB IDs		2IQP 2IQR 2IQS 2IQU 2IQV 2IQW 6W25	1X5D 3VWW 3W8J 4EF0 4GWR
Enriched GO Terms of Interacting Partners?
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