MAGEB4 and USP25

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		MAGEB4	USP25
Description		MAGE family member B4	ubiquitin specific peptidase 25
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS			Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		41 interacting genes: AARD ACOT11 ARID3A BLOC1S1 CCDC136 CCDC14 DVL3 EEF1AKMT3 FAM136A FAM166B FERD3L FLOT2 FTSJ3 GOLGA6L2 GPATCH2 H2AP HGS IHO1 KANK2 KRT38 LZTS2 MAGEA8 MED21 MESD NEUROD4 PFDN6 PICK1 PJA1 ROCK1 RUNDC3A SH2D1B THOC1 TNR TRAK1 UQCRB USHBP1 USP25 WDR62 YWHAE ZNF341 ZRANB1	22 interacting genes: ACTA1 FBXL17 FLNC GAPDH MAGEB4 MID2 MT2A NGEF PUS10 RAD23A RAD23B SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS UBC UBE2I ZNF426
Entrez ID		4115	29761
HPRD ID		02150	05296
Ensembl ID		ENSG00000120289	ENSG00000155313
Uniprot IDs		O15481	Q9UHP3
PDB IDs			2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?
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