USP25 and PUS10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		USP25	PUS10
Description		ubiquitin specific peptidase 25	pseudouridine synthase 10
Image
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding	Protein Binding Pseudouridine Synthase Activity Metal Ion Binding Primary MiRNA Binding TRNA Pseudouridine Synthase Activity
	Biological Process	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway	Primary MiRNA Processing TRNA Pseudouridine Synthesis
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Atopic dermatitis ( 26482879) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22412388) Crohn's disease and celiac disease ( 21298027) Erectile dysfunction ( 30583798) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244) Ulcerative colitis ( 28067908 20228799 21297633)
Interacting Genes		22 interacting genes: ACTA1 FBXL17 FLNC GAPDH MAGEB4 MID2 MT2A NGEF PUS10 RAD23A RAD23B SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS UBC UBE2I ZNF426	5 interacting genes: ABITRAM KRT14 KRT16 NECAB2 USP25
Entrez ID		29761	150962
HPRD ID		05296	08126
Ensembl ID		ENSG00000155313	ENSG00000162927
Uniprot IDs		Q9UHP3	A8K6R4 Q3MIT2
PDB IDs		2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM	2V9K
Enriched GO Terms of Interacting Partners?
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