SMAD1 and UBXN1

Number of citations of the paper that reports this interaction (PubMedID 15761153)
269

Data Source:
HPRD (in vivo)

		SMAD1	UBXN1
Description		SMAD family member 1	UBX domain protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Inner Membrane Nucleoplasm Cytoplasm Cytosol Integral Component Of Membrane Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Dendrite VCP-NPL4-UFD1 AAA ATPase Complex Neuronal Cell Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Protein Kinase Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding Primary MiRNA Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding
	Biological Process	MAPK Cascade Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Cardiac Conduction System Development Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Gamete Generation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Embryonic Pattern Specification Positive Regulation Of Gene Expression Cell Differentiation BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Muscle Cell Differentiation Cartilage Development Cardiac Muscle Cell Proliferation Bone Development SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Sprouting Angiogenesis	Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-specific Protease Activity
Pathways		Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development	N-glycan trimming in the ER and Calnexin/Calreticulin cycle Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Panic disorder ( 31712720) Red cell distribution width ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		161 interacting genes: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APC APP AR ARHGEF6 ARL4D AXIN2 BMPR1A BTBD2 BTG2 BUB1 CAMSAP1 CCND1 CDK7 CDK9 CHMP3 CILK1 COL4A1 CTNNA1 DACH1 DLC1 DNMT3L DVL1 ECSIT EIF2AK4 ELP3 EP300 EPN2 ERBB2 ERBIN EWSR1 FBXL12 FBXO30 FBXW7 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 LMNA MAP2K3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MLH1 MLH3 MRTFB MSH2 MUTYH NAT9 NEDD4 NEDD9 NEUROG1 NFE2L2 NKX3-2 NOTCH2 NRAS OAZ1 OAZ3 PAK1 PARD3 PDGFRL PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PTPN12 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STK11 STUB1 SUV39H1 TCF20 TET2 TGFBR1 TLR2 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4	20 interacting genes: ACOT7 ACVR1 BARD1 BMPR1B BRCA1 FAM189A2 HMGB1 HOMER2 PLA2G4A PLAA POLR3C RAD23A SMAD1 SMURF1 TGFBR1 TRIM39 UBC UBE2I UBQLN1 UBQLN2
Entrez ID		4086	51035
HPRD ID		03356	11266
Ensembl ID		ENSG00000170365	ENSG00000162191
Uniprot IDs		Q15797	A0A024R539 A0A024R598 A0A087WTZ5 Q04323
PDB IDs		1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 3Q47 3Q4A 5ZOK
Enriched GO Terms of Interacting Partners?
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