LOXL1 and FBLN5

Number of citations of the paper that reports this interaction (PubMedID 14745449)
228

Data Source:
BioGRID (pull down, affinity chromatography technology, two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		LOXL1	FBLN5
Description		lysyl oxidase like 1	fibulin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Basement Membrane Extracellular Space Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	Peptidyl-lysine Oxidation Protein Deamination Collagen Fibril Organization Response To Lipopolysaccharide Aorta Development	Regulation Of Cell Growth Cell-matrix Adhesion Protein Localization To Cell Surface Secretion Elastic Fiber Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		Elastic fibre formation Crosslinking of collagen fibrils	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Adult body size ( 32376654) Aortic root size ( 19584346) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Exfoliation syndrome ( 25706626) Glaucoma (exfoliation) ( 17690259) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Height ( 28552196 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Joint mobility (Beighton score) ( 27182965) Pelvic organ prolapse ( 32184442) Pseudoexfoliation syndrome ( 29278698) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Youthful appearance (self-reported) ( 32339537)	Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		4 interacting genes: ATXN1 ELN FBLN5 MFGE8	23 interacting genes: ATN1 GFI1B GSC HOXA1 LGMN LOXL1 LPA MEOX2 NDUFA4 NUFIP2 OTX1 PAXIP1 PDIA3 PPP2R5C PRNP PSMC1 SERPINA1 SERPINA5 SOD3 ST3GAL3 TOP3B TRIP13 XCL1
Entrez ID		4016	10516
HPRD ID		08861	05204
Ensembl ID		ENSG00000129038	ENSG00000140092
Uniprot IDs		Q08397	A0A024R6G3 Q9UBX5
PDB IDs
Enriched GO Terms of Interacting Partners?
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