LMNB1 and MELK

Number of citations of the paper that reports this interaction (PubMedID 16216881)
48

Data Source:
HPRD (in vivo)

		LMNB1	MELK
Description		lamin B1	maternal embryonic leucine zipper kinase
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane	Plasma Membrane Cell Cortex Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Phospholipase Binding Sequence-specific Double-stranded DNA Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding Protein Serine Kinase Activity
	Biological Process		G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Peptidyl-tyrosine Phosphorylation Hemopoiesis Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation
Pathways		Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerisation of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)
Interacting Genes		42 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA5 KPNA6 LBR LMNA M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ	11 interacting genes: CDC25B CDC5L EIF2S1 EZH2 H1-5 LMNB1 MAPT MBP PPP1R8 SF3B1 ZNF622
Entrez ID		4001	9833
HPRD ID		01036	06119
Ensembl ID		ENSG00000113368	ENSG00000165304
Uniprot IDs		B4DZT3 P20700	B7Z1G6 Q14680
PDB IDs		2KPW 3JT0 3TYY 3UMN 5VVX	4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC 5K00 5M5A 5MAF 5MAG 5MAH 5MAI 5TVT 5TWL 5TWU 5TWY 5TWZ 5TX3 6GVX 6VXR
Enriched GO Terms of Interacting Partners?
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