LEP and CRP

Number of citations of the paper that reports this interaction (PubMedID 16582918)
95

Data Source:
HPRD (in vivo, in vitro)

		LEP	CRP
Description		leptin	C-reactive protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Extracellular Region Extracellular Space
	Molecular Function	DNA Binding Hormone Activity Protein Binding Peptide Hormone Receptor Binding Leptin Receptor Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovulation From Ovarian Follicle Response To Hypoxia Placenta Development Positive Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Cardiac Muscle Hypertrophy Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Phagocytosis Tyrosine Phosphorylation Of STAT Protein Female Pregnancy Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Determination Of Adult Lifespan Adult Feeding Behavior Negative Regulation Of Autophagy Negative Regulation Of Lipid Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Sexual Reproduction Central Nervous System Neuron Development Insulin Secretion T Cell Differentiation Regulation Of Intestinal Cholesterol Absorption Positive Regulation Of TOR Signaling Negative Regulation Of Appetite Prostaglandin Secretion Response To Estradiol Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Proliferation Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Intracellular Signal Transduction Bone Mineralization Involved In Bone Maturation Aorta Development Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Import Into Nucleus Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Ion Transport Positive Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Response To Ethanol Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Negative Regulation Of Glucose Import Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of Bone Remodeling Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Intestinal Absorption Leukocyte Tethering Or Rolling Regulation Of Nitric-oxide Synthase Activity Elastin Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Regulation Of Brown Fat Cell Differentiation Bone Growth Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Fat Cell Apoptotic Process Activation Of Protein Kinase C Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium
Pathways		Signaling by Leptin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and deacylation of Ghrelin	Classical antibody-mediated complement activation
Drugs			N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases
GWAS		BMI at 1.5 years old ( 31575865) BMI at 8 months old ( 31575865) Body size at age 10 ( 32376654) circulating leptin levels ( 32917775 26833098) circulating leptin levels adjusted for BMI ( 32917775 26833098) High density lipoprotein cholesterol levels ( 29403010) Type 2 diabetes ( 26818947 23945395 32499647)	Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 33227023 24763700 29403010 33339817 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)
Interacting Genes		10 interacting genes: A2M CLU CRP GHRL HK3 HSF2BP LEPR PRKAA2 SIGLEC6 UCN	22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A
Entrez ID		3952	1401
HPRD ID		01249	00422
Ensembl ID		ENSG00000174697	ENSG00000132693
Uniprot IDs		A4D0Y8 P41159	P02741
PDB IDs		1AX8	1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?
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