CRP and H1-1

Number of citations of the paper that reports this interaction (PubMedID 1989977)
16

Data Source:
HPRD (in vivo)

		CRP	H1-1
Description		C-reactive protein	H1.1 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding	Double-stranded DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium	Nucleosome Assembly Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of DNA Recombination
Pathways		Classical antibody-mediated complement activation	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases
GWAS		Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 33227023 24763700 29403010 33339817 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)
Interacting Genes		22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A	52 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		1401	3024
HPRD ID		00422	00820
Ensembl ID		ENSG00000132693	ENSG00000124610
Uniprot IDs		P02741	Q02539
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?
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