JUP and PECAM1

Number of citations of the paper that reports this interaction (PubMedID 10801826)
28

Data Source:
HPRD (in vivo, in vitro)

		JUP	PECAM1
Description		junction plakoglobin	platelet and endothelial cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Cytoplasmic Side Of Plasma Membrane Intercalated Disc Actin Cytoskeleton Apicolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Hemidesmosome Desmosome Protein-DNA Complex Specific Granule Lumen Extracellular Exosome Gamma-catenin-TCF7L2 Complex Ficolin-1-rich Granule Lumen	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Secretory Granule Membrane Platelet Alpha Granule Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity Protein-containing Complex Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cytoskeletal Protein-membrane Anchor Activity	Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Desmosome Assembly Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Blood Vessel Endothelial Cell Migration Skin Development Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Detection Of Mechanical Stimulus Positive Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell-cell Adhesion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Positive Regulation Of Protein Phosphorylation Phagocytosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Cell Recognition Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Monocyte Extravasation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Diapedesis Establishment Of Endothelial Barrier Bicellular Tight Junction Assembly Glomerular Endothelium Development Neutrophil Extravasation Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Protein Localization To Cell-cell Junction
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Neutrophil degranulation Keratinization Formation of the cornified envelope RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle	Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation
Drugs		Zinc Zinc acetate
Diseases
GWAS		Heel bone mineral density ( 30598549 28869591) Major depressive disorder x sex interaction ( 34099189)	Coronary artery disease ( 32469254 29212778 33020668) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Systolic blood pressure ( 27841878)
Interacting Genes		53 interacting genes: APC ARHGDIA AXIN1 BIRC2 BRCA1 BTRC CDH1 CDH10 CDH15 CDH2 CDH5 CTNNA1 CTNNA3 CTNNBIP1 CTNND1 DDX6 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP EGFR ERBB2 ERBB3 FER FHL2 FYN HSP90AA1 MUC1 NFATC4 NFKBIE NTAQ1 PECAM1 PKD1 PKP2 PKP3 PRR35 PSEN1 PTEN PTPN14 PTPRF PTPRJ PTPRK RIBC2 RSPH14 SRC TBP TCF4 TCF7L2 YJU2B ZFYVE9	24 interacting genes: BRIP1 CD38 CSK CTNNB1 DSP EFNB2 FOXJ1 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1
Entrez ID		3728	5175
HPRD ID		01414	01425
Ensembl ID		ENSG00000173801	ENSG00000261371
Uniprot IDs		A0A0S2Z487 P14923	P16284
PDB IDs		3IFQ	2KY5 5C14 5GNI
Enriched GO Terms of Interacting Partners?
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