ITIH4 and DNAJC1

Number of citations of the paper that reports this interaction (PubMedID 16271702)
4

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ITIH4	DNAJC1
Description		inter-alpha-trypsin inhibitor heavy chain 4	DnaJ heat shock protein family (Hsp40) member C1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	ATPase Activator Activity DNA Binding Protein Binding Chaperone Binding
	Biological Process	Acute-phase Response Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Response To Cytokine	Regulation Of Translation Protein Folding Negative Regulation Of Proteolysis Regulation Of Protein Secretion Regulation Of Catalytic Activity
Pathways		Platelet degranulation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Blood protein levels ( 30072576) Body mass index ( 28552196 24861553) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-2) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Manganese levels ( 26025379) Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 28892059) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 21926974 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 23128233) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Aspartate aminotransferase levels ( 33339817) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Essential hypertension (time to event) ( 32589924) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Oily fish consumption ( 32066663) Ovarian cancer ( 23535730) Pork consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		4 interacting genes: DNAJC1 GRB2 KLK1 TP63	11 interacting genes: ABHD16A AGTRAP ATP6V0C CMTM7 CYP4F2 HSPA5 ITIH4 PLP2 SERPINA3 TMEM201 TNFRSF10C
Entrez ID		3700	64215
HPRD ID		02781	09922
Ensembl ID		ENSG00000055955	ENSG00000136770
Uniprot IDs		B2RMS9 B7ZKJ8 Q14624	Q96KC8
PDB IDs			2CQQ 2CQR
Enriched GO Terms of Interacting Partners?
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