ZBTB41 and DENND1B

		ZBTB41	DENND1B
Description		zinc finger and BTB domain containing 41	DENN domain containing 1B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytosol Nuclear Speck Clathrin-coated Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Endocytosis Protein Transport Endocytic Recycling Positive Regulation Of GTPase Activity Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23536807) Blood protein levels ( 28240269) Lupus nephritis in systemic lupus erythematosus ( 24925725)	Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)
Interacting Genes		2 interacting genes: DENND1B NEK7	5 interacting genes: ATP6V1G3 GLRX2 KCNT2 LNX1 ZBTB41
Entrez ID		360023	163486
HPRD ID		17017	13303
Ensembl ID		ENSG00000177888	ENSG00000213047
Uniprot IDs		Q5SVQ8	A0A024R987 Q6P3S1
PDB IDs			3TW8
Enriched GO Terms of Interacting Partners?
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