DENND1B

Description		DENN domain containing 1B
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GO Annotations	Cellular Component	Cytosol Nuclear Speck Clathrin-coated Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Endocytosis Protein Transport Endocytic Recycling Positive Regulation Of GTPase Activity Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Anxiety ( 33859377) Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin morphology ( 33593615) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Depression ( 29700475) Eye morphology ( 33593615) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)
Interacting Genes		5 interacting genes: ATP6V1G3 GLRX2 KCNT2 LNX1 ZBTB41
Entrez ID		163486
HPRD ID		13303
Ensembl ID		ENSG00000213047
Uniprot IDs		A0A024R987 Q6P3S1
PDB IDs		3TW8
Enriched GO Terms of Interacting Partners?
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