IL1RAP and MARCHF8

Number of citations of the paper that reports this interaction (PubMedID 22904187)
39

Data Source:
BioGRID (enzymatic study)

		IL1RAP	MARCHF8
Description		interleukin 1 receptor accessory protein	membrane associated ring-CH-type finger 8
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Glutamatergic Synapse	Cytoplasm Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Early Endosome Membrane Late Endosome Membrane
	Molecular Function	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Interleukin-1 Receptor Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding MHC Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Inflammatory Response Immune Response Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Protein Polyubiquitination Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)
Interacting Genes		22 interacting genes: AP2M1 CCNI FXR1 IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP	11 interacting genes: ARR3 CD86 CYB5B FA2H GOSR2 IL1RAP TMEM14C UBE2D1 UBE2D3 UBE2H VAMP2
Entrez ID		3556	220972
HPRD ID		04021	17466
Ensembl ID		ENSG00000196083	ENSG00000165406
Uniprot IDs		A8K6K4 Q9NPH3	A0A024R7U2 Q5T0T0
PDB IDs		3O4O 4DEP	2D8S
Enriched GO Terms of Interacting Partners?
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