IL1A and IL1R2

Number of citations of the paper that reports this interaction (PubMedID 7878046)
53

Data Source:
HPRD (in vitro)

		IL1A	IL1R2
Description		interleukin 1 alpha	interleukin 1 receptor type 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding Interleukin-1 Binding
	Biological Process	Fever Generation Positive Regulation Of Cytokine Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cellular Sodium Ion Homeostasis Apoptotic Process Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation In Thymus Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cell Division Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Immune Response Negative Regulation Of Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection	Interleukin-10 signaling Interleukin-1 signaling
Drugs		Rilonacept
Diseases
GWAS		Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)	Ankylosing spondylitis ( 23749187 20062062) Asthma ( 31619474) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576 29875488) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Inflammatory bowel disease ( 28067908 23128233) Parkinson's disease ( 32201043 28892059) Ulcerative colitis ( 21297633)
Interacting Genes		11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13	5 interacting genes: IL1A IL1B IL1RAP IL1RN USP15
Entrez ID		3552	7850
HPRD ID		00988	00995
Ensembl ID		ENSG00000115008	ENSG00000115590
Uniprot IDs		P01583	P27930
PDB IDs		1ITA 2ILA 2KKI 2L5X 5UC6	3O4O
Enriched GO Terms of Interacting Partners?
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