IL1A and NFKBIE

Number of citations of the paper that reports this interaction (PubMedID 10998424)
15

Data Source:
HPRD (in vitro)

		IL1A	NFKBIE
Description		interleukin 1 alpha	NFKB inhibitor epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Fibrillar Center Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding	Protein Binding
	Biological Process	Fever Generation Positive Regulation Of Cytokine Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cellular Sodium Ion Homeostasis Apoptotic Process Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation In Thymus Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cell Division Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cytoplasmic Sequestering Of Transcription Factor
Pathways		Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection	Activation of NF-kappaB in B cells
Drugs		Rilonacept
Diseases
GWAS		Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)	Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Rheumatoid arthritis ( 32723749 30423114 22446963 23028356 24390342)
Interacting Genes		11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13	21 interacting genes: ANKHD1 BYSL C1QBP COG7 CUL1 GUCA1B HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 NPR3 PEX6 POLH PPP6C REL RELA SKP1
Entrez ID		3552	4794
HPRD ID		00988	05181
Ensembl ID		ENSG00000115008	ENSG00000146232
Uniprot IDs		P01583	A0A024RD24 O00221 Q7LC14 Q96F31
PDB IDs		1ITA 2ILA 2KKI 2L5X 5UC6
Enriched GO Terms of Interacting Partners?
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