IGSF1 and ACVR1B

Number of citations of the paper that reports this interaction (PubMedID 11266516)
12

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		IGSF1	ACVR1B
Description		immunoglobulin superfamily member 1	activin A receptor type 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Integral Component Of Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Activin Receptor Complex
	Molecular Function	Protein Binding Coreceptor Activity Inhibin Binding Activin Receptor Antagonist Activity	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type I Activin-activated Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding
	Biological Process	Regulation Of Transcription, DNA-templated Negative Regulation Of Activin Receptor Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Central Nervous System Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Growth Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Development Of Primary Female Sexual Characteristics Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways			Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin
Drugs			ATP Fostamatinib
Diseases
GWAS		Age at voice drop ( 27182965) Menarche (age at onset) ( 27182965)	Adenocarcinoma ( 26732429) Age-related hearing impairment ( 24939585) Granulocyte count ( 27863252) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lung cancer ( 26732429) Neutrophil count ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum CC16 levels ( 32839289) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urate levels ( 23263486)
Interacting Genes		8 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10	25 interacting genes: ACVR2B BAG6 BAMBI BMPR2 FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L NODAL OS9 OTUB1 PRKACB RXRA SHMT2 SMAD2 SMAD4 SMAD7 SNX1 SNX2 TDGF1 TGFBRAP1 TUBA1A TUBA1C
Entrez ID		3547	91
HPRD ID		02138	03193
Ensembl ID		ENSG00000147255	ENSG00000135503
Uniprot IDs		Q8N6C5	P36896
PDB IDs
Enriched GO Terms of Interacting Partners?
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