IFIT3 and CYP2C8

Number of citations of the paper that reports this interaction (PubMedID 21163940)
36

Data Source:
BioGRID (two hybrid)

		IFIT3	CYP2C8
Description		interferon induced protein with tetratricopeptide repeats 3	cytochrome P450 family 2 subfamily C member 8
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Molecular_function RNA Binding Protein Binding Identical Protein Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Caffeine Oxidase Activity Aromatase Activity Estrogen 16-alpha-hydroxylase Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation Response To Virus Cellular Response To Interferon-alpha Negative Regulation Of Apoptotic Process Innate Immune Response Defense Response To Virus	Lipid Hydroxylation Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Epoxygenase P450 Pathway Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Omega-hydroxylase P450 Pathway
Pathways		Interferon alpha/beta signaling	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs
Drugs			Isoniazid Palmitic Acid (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Diseases
GWAS		Hormone measurements ( 30576415)	Blood metabolite levels ( 24816252) Gout ( 22179738) Immune response to smallpox vaccine (IL-6) ( 22542470) Low density lipoprotein cholesterol levels ( 33339817) Osteonecrosis of the jaw ( 18594024) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Response to clopidogrel therapy ( 19706858) Serum metabolite levels ( 33031748) Total cholesterol levels ( 33339817) Triglyceride levels in HIV infection ( 33109212) Tuberculosis ( 24057671) Urinary metabolite levels in chronic kidney disease ( 31959995) Warfarin maintenance dose ( 23755828)
Interacting Genes		20 interacting genes: A2M APOE CYP2C8 DEUP1 ECSIT FANCA HAUS1 IFIT1 IFIT1B IFIT2 IFIT5 LONP1 LVRN MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM1 TPM3	12 interacting genes: A2M APOE BLMH DNAJB1 ECSIT EXOC6 IFIT3 LONP1 MAST1 PSEN1 RIN3 RNF32
Entrez ID		3437	1558
HPRD ID		05228	03083
Ensembl ID		ENSG00000119917	ENSG00000138115
Uniprot IDs		O14879 Q5T765	B7Z1F5 P10632
PDB IDs		6C6K	1PQ2 2NNH 2NNI 2NNJ 2VN0
Enriched GO Terms of Interacting Partners?
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