ABCB5 and CCND2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
52

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ABCB5	CCND2
Description		ATP binding cassette subfamily B member 5	cyclin D2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Membrane Cyclin D2-CDK4 Complex
	Molecular Function	ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Eye Development Cell Differentiation Regulation Of Membrane Potential Xenobiotic Transport Transmembrane Transport	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Long-term Memory Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Cellular Response To X-ray Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		ABC-family proteins mediated transport	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs		Biricodar Dofequidar
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31959851 30929738 34103634 32296059) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Dental caries ( 23259602) Eosinophil counts ( 29403010) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Prostate cancer ( 23535732) Response to statin therapy ( 20339536) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Brown vs. black hair color ( 30531825) Colorectal cancer ( 30529582 26151821 24836286 31826910 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28552196 28270201) Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 32203549 32154731 31928498) Type 2 diabetes ( 22885922 30054458 29358691 30297969 31118516 32499647 28869590) Waist circumference ( 31928498)
Interacting Genes		8 interacting genes: CCND2 CD44 EPHA2 ERBB2 FGFR4 PSMB5 RAF1 STK11	67 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARID5B ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD27 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAD1L1 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2
Entrez ID		340273	894
HPRD ID		12402	00451
Ensembl ID		ENSG00000004846	ENSG00000118971
Uniprot IDs		A0A024RA03 Q2M3G0	P30279
PDB IDs			6EI2
Enriched GO Terms of Interacting Partners?
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