C2orf74 and COMMD1

		C2orf74	COMMD1
Description		chromosome 2 open reading frame 74	copper metabolism domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Cul2-RING Ubiquitin Ligase Complex Recycling Endosome
	Molecular Function	Protein Binding	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process		Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface
Pathways			Neddylation
Drugs
Diseases
GWAS		Crohn's disease ( 22412388 21102463) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 23128233)	Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)
Interacting Genes		6 interacting genes: AHSA2P COMMD1 PNPT1 POT1 SMAGP TMEM17	34 interacting genes: BAHCC1 BARD1 BRCA1 C2orf74 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC HMGB2 KAT2A LIG4 NFKBIA PRKN RELA SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 UPRT WDPCP XIAP
Entrez ID		339804	150684
HPRD ID		19550	06253
Ensembl ID		ENSG00000237651	ENSG00000173163
Uniprot IDs		A8MZ97 C9JBF1	Q8N668
PDB IDs			2H2M
Enriched GO Terms of Interacting Partners?
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