KRTAP13-2 and GPS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KRTAP13-2	GPS2
Description		keratin associated protein 13-2	G protein pathway suppressor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrion Cytosol Transcription Repressor Complex
	Molecular Function	Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways		Keratinization	PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		80 interacting genes: ANAPC11 ANXA11 BCL6 C11orf1 C22orf39 CBFA2T2 CCDC125 CCDC24 CCDC57 CCNK CRYBA1 CSKMT CYSRT1 ENKD1 EPDR1 ETFDH FANCL FBXO17 FCHO1 GATA3 GEMIN4 GNE GPS2 GRN HNRNPH1 HOXA1 HR KCTD9 KLHL38 KPRP KRT3 KRTAP1-1 KRTAP10-5 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-4 KRTAP4-5 KRTAP9-2 MAGOHB MEOX2 MGAT5B NBPF19 NEK8 NHLRC4 NOTCH2NLA OIP5 OTX1 P4HB PATZ1 PHETA1 PITX1 POU2AF1 PPP1R32 RECK RHOXF2 SLC25A18 SLIT1 SMUG1 SNRPC SPEF1 SSC4D STK16 TCAF1 TEX37 TLE5 TNS2 TRAPPC6A TRIM68 TSPYL6 TSSK3 UNC5CL VGLL3 VWC2 YPEL3 ZIC1	55 interacting genes: AKAP8L ATF4 ATF5 BAG4 BRME1 C19orf54 CCNA1 CHD3 CNOT2 CYSRT1 DAZAP2 ELOB EP300 FAM168B FHL5 GOLGA2 HDAC1 HDAC3 HNRNPH1 HOXA1 INTS11 KRT27 KRT31 KRT34 KRT36 KRTAP11-1 KRTAP13-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 MAP3K7CL MYH10 NCOR1 NDOR1 NR0B2 OIP5 PBK POU2AF1 PRMT6 PRR22 RBPMS SESTD1 SETDB1 SMUG1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53 TP53BP2 TRIP6 UBTD2 VPS37C
Entrez ID		337959	2874
HPRD ID		11201	11878
Ensembl ID		ENSG00000182816	ENSG00000132522
Uniprot IDs		Q52LG2	Q13227
PDB IDs			2L5G
Enriched GO Terms of Interacting Partners?
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