GPS2 and PBK

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GPS2	PBK
Description		G protein pathway suppressor 2	PDZ binding kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrion Cytosol Transcription Repressor Complex	Nucleus
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity GTPase Inhibitor Activity Protein Binding Cyclin Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II JNK Cascade Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Metabolic Process B Cell Differentiation Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Receptor Signaling Pathway Response To Mitochondrial Depolarisation Negative Regulation Of Protein K63-linked Ubiquitination	MAPK Cascade Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To UV Negative Regulation Of Inflammatory Response
Pathways		PPARA activates gene expression HDACs deacetylate histones Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		55 interacting genes: AKAP8L ATF4 ATF5 BAG4 BRME1 C19orf54 CCNA1 CHD3 CNOT2 CYSRT1 DAZAP2 ELOB EP300 FAM168B FHL5 GOLGA2 HDAC1 HDAC3 HNRNPH1 HOXA1 INTS11 KRT27 KRT31 KRT34 KRT36 KRTAP11-1 KRTAP13-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 MAP3K7CL MYH10 NCOR1 NDOR1 NR0B2 OIP5 PBK POU2AF1 PRMT6 PRR22 RBPMS SESTD1 SETDB1 SMUG1 SPDL1 TBL1X TBL1XR1 TFIP11 TP53 TP53BP2 TRIP6 UBTD2 VPS37C	20 interacting genes: ARAF CCNB1 CDK1 CEP126 DLG1 GPRASP1 GPS2 H2AX LNX1 MCRS1 PTEN RAF1 SH2D4A SMAD4 TERT TP53 TRIM37 ZBTB26 ZFP64 ZNF526
Entrez ID		2874	55872
HPRD ID		11878	17822
Ensembl ID		ENSG00000132522	ENSG00000168078
Uniprot IDs		Q13227	Q96KB5 V9HWH0
PDB IDs		2L5G	5J0A
Enriched GO Terms of Interacting Partners?
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