HSPD1 and PPP2R1B

Number of citations of the paper that reports this interaction (PubMedID 17540176)
97

Data Source:
HPRD (in vivo)

		HSPD1	PPP2R1B
Description		heat shock protein family D (Hsp60) member 1	protein phosphatase 2 scaffold subunit Abeta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Peroxisomal Matrix Rough Endoplasmic Reticulum Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Mitochondrial Crista Coated Vesicle Secretory Granule Golgi Cisterna Protein-containing Complex Zymogen Granule Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome Sperm Midpiece	Protein Phosphatase Type 2A Complex Cytoplasm Membrane Raft Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATP Hydrolysis Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Unfolded Protein Binding Chaperone Binding Modification-dependent Protein Binding	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Response To Hypoxia MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Ischemia Protein Folding 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Response To Xenobiotic Stimulus Response To Activity Response To Lipopolysaccharide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Response To ATP Mitochondrial Unfolded Protein Response Cellular Response To Heat Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Response To Cocaine Response To Hydrogen Peroxide Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Positive Regulation Of Inflammatory Response Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Response To Glucocorticoid Protein Maturation Biological Process Involved In Interaction With Symbiont Negative Regulation Of Apoptotic Process In Bone Marrow Cell Cellular Response To Interleukin-7 Negative Regulation Of Reactive Oxygen Species Biosynthetic Process	Protein Dephosphorylation Regulation Of Catalytic Activity Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation
Drugs		Copper
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red blood cell count ( 32888494)
Interacting Genes		61 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP6 CASP9 CEP70 CLEC7A CLU CYSRT1 DHFR DUX4 ERBB2 ERG FAM107A FHIT GLI2 H2BC21 HSPE1 ITGA3 ITGB1 KCTD10 KRT31 KRT34 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LINC01554 LRRK2 LZTS2 MAPK6 MCPH1 MGAT3 MOB4 NOS1AP NOTCH2NLA NR3C1 OGT PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SF3B1 SUMO2 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 UBASH3A YWHAG	43 interacting genes: AKAP9 ANXA5 BHLHE41 BSG CDK1 CDK4 CEP43 CFTR CLOCK CRY1 CRY2 CSNK2B DELEC1 EEF2 FBXW11 HDAC1 HSPD1 HYOU1 JAK2 MCM3 OGT PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA RORC SET SGO1 SGO2 STRN STRN3 TIMM8B UNC5B
Entrez ID		3329	5519
HPRD ID		00318	04384
Ensembl ID		ENSG00000144381	ENSG00000137713
Uniprot IDs		A0A024R3X4 P10809	P30154
PDB IDs		4PJ1 6HT7 6MRC 6MRD 7AZP
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?