HSPD1 and GLI2

		HSPD1	GLI2
Description		heat shock protein family D (Hsp60) member 1	GLI family zinc finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Peroxisomal Matrix Rough Endoplasmic Reticulum Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Mitochondrial Crista Coated Vesicle Secretory Granule Golgi Cisterna Protein-containing Complex Zymogen Granule Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome Sperm Midpiece	Nucleus Nucleoplasm Nucleolus Cytosol Cilium Axoneme Membrane Nuclear Speck Motile Cilium Ciliary Tip Ciliary Base
	Molecular Function	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATP Hydrolysis Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Unfolded Protein Binding Chaperone Binding Modification-dependent Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Response To Hypoxia MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Ischemia Protein Folding 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Response To Xenobiotic Stimulus Response To Activity Response To Lipopolysaccharide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Response To ATP Mitochondrial Unfolded Protein Response Cellular Response To Heat Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Response To Cocaine Response To Hydrogen Peroxide Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Positive Regulation Of Inflammatory Response Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Response To Glucocorticoid Protein Maturation Biological Process Involved In Interaction With Symbiont Negative Regulation Of Apoptotic Process In Bone Marrow Cell Cellular Response To Interleukin-7 Negative Regulation Of Reactive Oxygen Species Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development In Utero Embryonic Development Kidney Development Chondrocyte Differentiation Osteoblast Development Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Hair Follicle Morphogenesis Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Notochord Regression Prostatic Bud Formation Mammary Gland Duct Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Organic Cyclic Compound Cochlea Morphogenesis Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways		Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Degradation of GLI2 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates chondrocyte maturation
Drugs		Copper
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Acne (severe) ( 30542056) Age-related macular degeneration ( 23326517) Breast size ( 22747683) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Erectile dysfunction and prostate cancer treatment ( 20932654) Estimated glomerular filtration rate ( 31015462) Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046) Glomerular filtration rate (creatinine) ( 26831199) Height ( 28552196 25429064 31562340) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211) Type 2 diabetes ( 30054458 30297969) Waist circumference adjusted for body mass index ( 34021172) Weight ( 34074324)
Interacting Genes		61 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP6 CASP9 CEP70 CLEC7A CLU CYSRT1 DHFR DUX4 ERBB2 ERG FAM107A FHIT GLI2 H2BC21 HSPE1 ITGA3 ITGB1 KCTD10 KRT31 KRT34 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LINC01554 LRRK2 LZTS2 MAPK6 MCPH1 MGAT3 MOB4 NOS1AP NOTCH2NLA NR3C1 OGT PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SF3B1 SUMO2 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 UBASH3A YWHAG	13 interacting genes: AR BTRC CREB1 FBXW11 HSPD1 OTUB2 SKI SPOP STK36 SUFU TAF9 ZIC1 ZIC2
Entrez ID		3329	2736
HPRD ID		00318	01312
Ensembl ID		ENSG00000144381	ENSG00000074047
Uniprot IDs		A0A024R3X4 P10809	P10070 Q1PSW9 Q59FV5
PDB IDs		4PJ1 6HT7 6MRC 6MRD 7AZP
Enriched GO Terms of Interacting Partners?
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