HPR and DYNC1LI2

		HPR	DYNC1LI2
Description		haptoglobin-related protein	dynein cytoplasmic 1 light intermediate chain 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle	Kinetochore Lysosome Late Endosome Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Membrane
	Molecular Function	Serine-type Endopeptidase Activity Hemoglobin Binding	ATP Binding Identical Protein Binding Dynein Heavy Chain Binding
	Biological Process	Acute Inflammatory Response Positive Regulation Of Cell Death Zymogen Activation	Microtubule Cytoskeleton Organization Microtubule-based Movement Centrosome Localization Cellular Response To Nerve Growth Factor Stimulus
Pathways		Scavenging of heme from plasma	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		Zinc Copper Zinc acetate
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Apolipoprotein A1 levels ( 33730874) Aspartate aminotransferase levels ( 33547301 34315874) Blood protein levels ( 28240269) Cholesterol, total ( 24097068 28270201 25961943 20686565 26582766) Coronary artery disease ( 32469254 33020668) Hematocrit ( 32888494) LDL cholesterol ( 24097068 25961943 20686565 26582766) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731 33339817) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Lipid traits ( 30576415)
Interacting Genes		6 interacting genes: APOA1 DYNC1LI2 HSP90AA1 IGHM PSKH1 VKORC1	9 interacting genes: APP BRCA2 CTRL DMTN FCSK GAA HPR OGT ZFHX3
Entrez ID		3250	1783
HPRD ID		00773	09923
Ensembl ID		ENSG00000261701	ENSG00000135720
Uniprot IDs		P00739	A0A024R6Z0 O43237 Q63HJ8
PDB IDs			6F1T 6F1Y 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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