NR4A1 and ABCG8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NR4A1	ABCG8
Description		nuclear receptor subfamily 4 group A member 1	ATP binding cassette subfamily G member 8
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrion Cytosol Nuclear Membrane Presynapse	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Glucocorticoid Receptor Binding Identical Protein Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding ATP Binding ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Metal Ion Binding Protein Heterodimerization Activity Cholesterol Transfer Activity ABC-type Transporter Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Response To Amphetamine Cell Migration Involved In Sprouting Angiogenesis Regulation Of Transcription By RNA Polymerase II Apoptotic Process Signal Transduction Neurotransmitter Secretion Involved In Regulation Of Skeletal Muscle Contraction Intracellular Receptor Signaling Pathway Response To Lipopolysaccharide Endothelial Cell Chemotaxis Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Electrical Stimulus Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus	Response To Nutrient Excretion Response To Xenobiotic Stimulus Negative Regulation Of Intestinal Phytosterol Absorption Response To Muscle Activity Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Bile Acid Signaling Pathway Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport Triglyceride Homeostasis Intermembrane Lipid Transfer
Pathways		AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer	ABC transporters in lipid homeostasis Defective ABCG8 causes GBD4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 28270201 25961943 20686565) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gallstone disease ( 30325047 30504769 30692554 27094239 17632509) LDL cholesterol ( 23726366 19060906 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731 33339817) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Phytosterol levels ( 20529992) Refractive error ( 32231278) Total cholesterol levels ( 33339817 30275531)
Interacting Genes		88 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 ERBB3 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579	9 interacting genes: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 MESD NR4A1 NUPR1
Entrez ID		3164	64241
HPRD ID		00744	05679
Ensembl ID		ENSG00000123358	ENSG00000143921
Uniprot IDs		A0A024R126 F5GXF0 P22736 Q6ZMM6	Q9H221
PDB IDs		2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1	5DO7
Enriched GO Terms of Interacting Partners?
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