HDAC2 and SP1

Number of citations of the paper that reports this interaction (PubMedID 12151407)
66

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		HDAC2	SP1
Description		histone deacetylase 2	Sp1 transcription factor
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytoplasm Sin3 Complex NuRD Complex Protein-containing Complex ESC/E(Z) Complex	Chromatin Euchromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	Chromatin Binding RNA Binding Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Sequence-specific DNA Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding HMG Box Domain Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Cardiac Muscle Hypertrophy Chromatin Remodeling Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Epidermal Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Dendrite Development Histone Deacetylation Response To Caffeine Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Heat Response To Nicotine Response To Cocaine Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Ethanol Positive Regulation Of Oligodendrocyte Differentiation Response To Hyperoxia Hair Follicle Placode Formation Negative Regulation Of Dendritic Spine Development Eyelid Development In Camera-type Eye Fungiform Papilla Formation Cellular Response To Hydrogen Peroxide Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Male Mating Behavior Cellular Response To Dopamine Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Peptidyl-lysine Acetylation	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Cellular Response To Insulin Stimulus Response To Hydroperoxide Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation By Host Of Viral Transcription Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Factors involved in megakaryocyte development and platelet production	PPARA activates gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Activation of gene expression by SREBF (SREBP) Oncogene Induced Senescence RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Estrogen-dependent gene expression
Drugs		Pravastatin Lovastatin Theophylline Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Oxtriphylline Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Tixocortol Mocetinostat
Diseases
GWAS		Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Metabolite levels ( 23823483)	Apolipoprotein B levels ( 32203549) High light scatter reticulocyte count ( 32888494) Hypospadias (moderate to severe) ( 31856834) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 27863252) Parkinsonism in frontotemporal lobe dementia ( 29724592) Percentage gas trapping ( 26030696) Progressive supranuclear palsy ( 30089514) Red blood cell count ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		106 interacting genes: ANTXR1 APPL1 ARID4A AURKA BCL11A BRCA1 BRMS1 BRMS1L BUB3 CABIN1 CDC20 CDH1 CDKN1A CDYL CHD3 CHFR CIR1 CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 ERCC6 FKBP3 FOXO3 FTCD FYN GATA3 H2AC1 H2AC20 H2BC21 H3-4 H3C1 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HOPX HUWE1 IFRD1 IKZF1 IKZF4 ING1 LAMA4 MAD1L1 MBD2 MBD3L2 MEN1 MTA1 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA REV3L RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 STK25 SUMO2 SUV39H1 SYK TFCP2 THRA THRB TNS4 TOP2A TOP2B TP53 TREML2 USP4 VHL YY1 ZBTB16 ZNF461	152 interacting genes: AATF AHR AKT1 AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 CTCFL CTNNB1 DDX5 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 ENDOU EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 GRIN1 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HNRNPA1 HOXC11 HSPA8 HTT IL1B JUN KIF1A KLF10 KLF4 KLF6 LDB1 LMO2 MAPK1 MAPK3 MAPK8 MBD1 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MTREX MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NEDD4L NEPRO NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NPM1 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RAPGEF3 RARA RB1 RBBP4 RBL1 REG1A REL RELA RNF4 RORA RXRA SENP6 SF3A1 SHC1 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO2 TAF4 TAL1 TBP TLX3 TP53 TP73 TPI1 USP39 VEGFA VHL YY1 ZBTB16 ZBTB2 ZBTB7A
Entrez ID		3066	6667
HPRD ID		05521	01796
Ensembl ID		ENSG00000196591	ENSG00000185591
Uniprot IDs		Q92769	P08047
PDB IDs		3MAX 4LXZ 4LY1 5IWG 5IX0 6G3O 6WBW 6WBZ 6XDM 6XEB 6XEC 7KBG 7KBH	1SP1 1SP2 1VA1 1VA2 1VA3 6PV0 6PV1 6PV2 6PV3 6UCO 6UCP
Enriched GO Terms of Interacting Partners?
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