HCLS1 and LYN

Number of citations of the paper that reports this interaction (PubMedID 7682714)
45

Data Source:
HPRD (in vivo, in vitro)

		HCLS1	LYN
Description		hematopoietic cell-specific Lyn substrate 1	LYN proto-oncogene, Src family tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Actin Filament Plasma Membrane Site Of Polarized Growth Cortical Actin Cytoskeleton	Nucleus Cytoplasm Mitochondrial Intermembrane Space Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Adherens Junction Postsynaptic Density Mitochondrial Crista Endocytic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Integrin Alpha2-beta1 Complex Intracellular Membrane-bounded Organelle Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding ATP Binding Kinase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding Gamma-tubulin Binding Glycosphingolipid Binding Transmembrane Transporter Binding Ephrin Receptor Binding Phosphoprotein Binding Scaffold Protein Binding Phosphorylation-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization	B Cell Homeostasis Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Histamine Secretion By Mast Cell Platelet Degranulation Negative Regulation Of Myeloid Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of B Cell Apoptotic Process Protein Phosphorylation Cellular Response To DNA Damage Stimulus Response To Sterol Depletion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Toxic Substance Response To Hormone Response To Carbohydrate Positive Regulation Of Neuron Projection Development Oligodendrocyte Development Response To Organic Cyclic Compound Peptidyl-tyrosine Phosphorylation Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Neuron Projection Development T Cell Costimulation Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Extracellular Stimulus Response To Insulin Regulation Of Mast Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Amino Acid Regulation Of Mast Cell Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Erythrocyte Differentiation Protein Autophosphorylation Ephrin Receptor Signaling Pathway Response To Axon Injury Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Cellular Component Movement Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Retinoic Acid Regulation Of Monocyte Chemotaxis Regulation Of Platelet Aggregation Dendritic Cell Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways			GPVI-mediated activation cascade Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Dectin-2 family CD209 (DC-SIGN) signaling CD22 mediated BCR regulation Cyclin D associated events in G1 Platelet Adhesion to exposed collagen Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Dasatinib 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Bosutinib Ponatinib Nintedanib Fostamatinib
Diseases
GWAS			Granulocyte count ( 27863252) Height ( 18391951) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Platelet count ( 32888494) Refractive error ( 32231278) Serum thyroid-stimulating hormone levels ( 24852370) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) White blood cell count ( 29403010 32888494 27863252)
Interacting Genes		24 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	137 interacting genes: ACTB ADAM15 AGXT AR ARFGEF1 BANK1 BCAR1 BTK CASP3 CASP7 CASP9 CBL CBLC CD19 CD22 CD36 CD72 CD79A CD79B CDK1 CDK2 CDKN1B CHST15 CLCF1 COASY CREBBP CRH CRKL CSF1R CSF2RA CSF2RB CSF3R CSK CSNK2B CTLA4 DAPP1 DLG4 DOK1 DOK2 DOK3 EGFR EPOR ERBB3 ERBB4 EVL FASLG FCAR FCER1G FCGR2A FCGR2B FOLR1 GAB2 GAB3 GP6 GRIA3 HCLS1 HNRNPK IGHA1 IL1B IL2RB IL7 IL7R INPP5D ITPR1 JAK2 KHDRBS1 KIT KLHL41 LCP2 LIME1 MAP4K1 MAPK3 MATK MET MME MS4A1 MS4A2 MUC1 NDFIP2 NEDD9 NEK7 NMT1 NPHS1 PAG1 PAK2 PDCD4 PDE4A PDE4D PECAM1 PIK3CG PILRB PLCG1 PLCG2 PNMA2 PPP1R15A PPP1R8 PRAM1 PRKCD PRKCQ PRKDC PRRG4 PTK2 PTK2B PTPN6 PTPRC RASA1 RGS16 RPL10 RPS6KB1 RPS6KB2 SGK3 SH2B2 SHC1 SKAP1 SKAP2 SLC4A1 SNCA SOCS1 SPHK1 SPHK2 SRC STAT3 SYK TEC TERF1 TNF TRAT1 TRIM28 TRIM55 TRIM63 TRIP10 TRPA1 TRPV4 TYK2 UBB UHRF2 UNC119
Entrez ID		3059	4067
HPRD ID		03199	01301
Ensembl ID		ENSG00000180353	ENSG00000254087
Uniprot IDs		P14317	A8K379 P07948 Q6NUK7
PDB IDs			1W1F 1WA7 3A4O 5XY1 6NMW
Enriched GO Terms of Interacting Partners?
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