SLC40A1 and NAT8

		SLC40A1	NAT8
Description		solute carrier family 40 member 1	N-acetyltransferase 8 (putative)
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Cysteine-S-conjugate N-acetyltransferase Activity
	Biological Process	Cellular Iron Ion Homeostasis Iron Ion Transmembrane Transport Iron Ion Homeostasis Multicellular Organismal Iron Ion Homeostasis Iron Ion Export Across Plasma Membrane	Glutathione Metabolic Process Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Negative Regulation Of Apoptotic Process Amyloid-beta Metabolic Process Amyloid Fibril Formation
Pathways		Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport	Amyloid fiber formation
Drugs
Diseases
GWAS		Bone fracture in osteoporosis ( 28580392) Hematocrit ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Liver iron content ( 34128465) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 32888494) Restless legs syndrome ( 33239738)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 23535967) Glomerular filtration rate (creatinine) ( 28452372) Hemoglobin levels ( 32327693) Macrovascular complications in type 2 diabetes ( 33430853) Metabolic traits ( 21886157) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 33031748 24625756 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 26352407)
Interacting Genes		4 interacting genes: GOLM1 HAMP NAT8 SLC22A2	36 interacting genes: ARL13B ATP6V0E1 BIK CD3E CD59 CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MFSD14B MTIF3 NAT8B REEP2 SAR1A SLC10A6 SLC40A1 SMAD4 SMYD5 SSB ST6GAL1 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TSPAN31 YIPF4
Entrez ID		30061	9027
HPRD ID		05229	08413
Ensembl ID		ENSG00000138449	ENSG00000144035
Uniprot IDs		Q9NP59	Q9UHE5
PDB IDs		6W4S 6WBV
Enriched GO Terms of Interacting Partners?
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