SLC40A1

Description		solute carrier family 40 member 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding
	Biological Process	Cellular Iron Ion Homeostasis Iron Ion Transmembrane Transport Iron Ion Homeostasis Multicellular Organismal Iron Ion Homeostasis Iron Ion Export Across Plasma Membrane
Pathways		Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport
Drugs
Diseases
GWAS		Bone fracture in osteoporosis ( 28580392) Hematocrit ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Liver iron content ( 34128465) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 32888494) Restless legs syndrome ( 33239738)
Interacting Genes		4 interacting genes: GOLM1 HAMP NAT8 SLC22A2
Entrez ID		30061
HPRD ID		05229
Ensembl ID		ENSG00000138449
Uniprot IDs		Q9NP59
PDB IDs		6W4S 6WBV
Enriched GO Terms of Interacting Partners?
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