SH3KBP1 and SHKBP1

Number of citations of the paper that reports this interaction (PubMedID 11152963)
16

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SH3KBP1	SHKBP1
Description		SH3 domain containing kinase binding protein 1	SH3KBP1 binding protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse	Lysosome
	Molecular Function	Protein Binding SH3 Domain Binding	Protein Binding Identical Protein Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Homooligomerization
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	CDC42 GTPase cycle
Drugs
Diseases
GWAS		Platelet count ( 32888494)	Carotid intima media thickness (mean) ( 31801372) Cleft lip with or without cleft palate x maternal periconceptional smoking interaction (parent of origin effect) ( 31372216) Hemoglobin levels ( 32327693)
Interacting Genes		60 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BHLHB9 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MET MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	12 interacting genes: CCNG1 COL7A1 CUL3 GRB2 HSP90AA1 HSP90AB1 LXN NR3C1 PIN1 PRPF3 SH3KBP1 YWHAG
Entrez ID		30011	92799
HPRD ID		02301	15338
Ensembl ID		ENSG00000147010	ENSG00000160410
Uniprot IDs		B7Z6E8 Q5JPT6 Q96B97	B3KVX8 Q8TBC3
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	4CRH
Enriched GO Terms of Interacting Partners?
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