SH3KBP1 and GGN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SH3KBP1	GGN
Description		SH3 domain containing kinase binding protein 1	gametogenetin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Protein Binding SH3 Domain Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Regulation Of Cell Shape Cell Migration Positive Regulation Of B Cell Activation	Double-strand Break Repair Gamete Generation Spermatogenesis Cell Differentiation
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Platelet count ( 32888494)
Interacting Genes		60 interacting genes: ABI2 ANKS1A ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BHLHB9 BLNK BMPR1B CAPZA1 CBL CBLB CCDC57 CCDC88B CD2 CYSRT1 DENND2A EGLN1 GGN GRB2 HCK HIVEP1 INPP5D ITSN2 KPRP KRTAP6-3 LZTS2 MET MVB12A NEDD4 NELFA PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 POLR2K PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 TP53BP2 UBB UBC UBE2I ZBTB7B ZNF219	25 interacting genes: ABI2 BAG3 BRCA1 CYSRT1 ECT2 FANCL GGNBP1 GGNBP2 GOLGA2 GRB2 HOMER3 HSF2BP KRT40 KRTAP2-3 KRTAP2-4 KRTAP5-9 MTUS2 NCK2 OAZ3 OSTF1 RACK1 SH3KBP1 SH3RF1 WWP2 ZMYND19
Entrez ID		30011	199720
HPRD ID		02301	17036
Ensembl ID		ENSG00000147010	ENSG00000179168
Uniprot IDs		B7Z6E8 Q5JPT6 Q96B97	Q86UU5
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS
Enriched GO Terms of Interacting Partners?
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