PUS10 and USP25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PUS10	USP25
Description		pseudouridine synthase 10	ubiquitin specific peptidase 25
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Nucleus Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding Pseudouridine Synthase Activity Metal Ion Binding Primary MiRNA Binding TRNA Pseudouridine Synthase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding
	Biological Process	Primary MiRNA Processing TRNA Pseudouridine Synthesis	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Atopic dermatitis ( 26482879) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22412388) Crohn's disease and celiac disease ( 21298027) Erectile dysfunction ( 30583798) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244) Ulcerative colitis ( 28067908 20228799 21297633)	Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		5 interacting genes: ABITRAM KRT14 KRT16 NECAB2 USP25	22 interacting genes: ACTA1 FBXL17 FLNC GAPDH MAGEB4 MID2 MT2A NGEF PUS10 RAD23A RAD23B SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS UBC UBE2I ZNF426
Entrez ID		150962	29761
HPRD ID		08126	05296
Ensembl ID		ENSG00000162927	ENSG00000155313
Uniprot IDs		A8K6R4 Q3MIT2	Q9UHP3
PDB IDs		2V9K	2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?
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