ORMDL2 and RNF41

		ORMDL2	RNF41
Description		ORMDL sphingolipid biosynthesis regulator 2	ring finger protein 41
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Integral Component Of Membrane SPOTS Complex	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Sphingolipid de novo biosynthesis	Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Asthma ( 31619474) Height ( 34054925)
Interacting Genes		22 interacting genes: AQP6 CD79A CREB3L1 CYB561 CYB5R3 DAPK1 EBP ELOVL4 FAM210B FCER1G GJA8 KCNJ6 MMGT1 RETREG3 RNF41 SCN3B SLC10A1 TMEM120A TMEM31 TMEM86B TMX2 ZDHHC15	49 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 CLEC9A ENOPH1 ERBB3 ERBB4 GDF11 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 NEUROD4 ORMDL2 PPP1R1A RAD23A RFC4 RNF166 RRM2B SRR SUOX TBATA TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 VPS52 ZAP70
Entrez ID		29095	10193
HPRD ID		17802	11520
Ensembl ID		ENSG00000123353	ENSG00000181852
Uniprot IDs		Q53FV1	A0A024RB33 Q9H4P4
PDB IDs			2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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