SPCS1 and TMEM74

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPCS1	TMEM74
Description		signal peptidase complex subunit 1	transmembrane protein 74
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Autophagosome Membrane Lysosomal Membrane Integral Component Of Membrane Cytoplasmic Vesicle
	Molecular Function	Molecular_function Protein Binding Peptidase Activity	Protein Binding
	Biological Process	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER	Macroautophagy
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256 25056061 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Male-pattern baldness ( 27182965)
Interacting Genes		10 interacting genes: AQP2 FIS1 FXYD6-FXYD2 NAALAD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2	7 interacting genes: AQP6 FATE1 LIME1 LMNA MS4A13 SPCS1 TMEM42
Entrez ID		28972	157753
HPRD ID		07155	08702
Ensembl ID		ENSG00000114902	ENSG00000164841
Uniprot IDs		Q9Y6A9	A0A024R9D4 Q96NL1
PDB IDs
Enriched GO Terms of Interacting Partners?
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