TMEM74 and SPCS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM74	SPCS1
Description		transmembrane protein 74	signal peptidase complex subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Lysosomal Membrane Integral Component Of Membrane Cytoplasmic Vesicle	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Molecular_function Protein Binding Peptidase Activity
	Biological Process	Macroautophagy	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER
Pathways			SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Male-pattern baldness ( 27182965)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Feeling worry ( 29500382) Schizophrenia ( 28991256 25056061 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: AQP6 FATE1 LIME1 LMNA MS4A13 SPCS1 TMEM42	10 interacting genes: AQP2 FIS1 FXYD6-FXYD2 NAALAD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2
Entrez ID		157753	28972
HPRD ID		08702	07155
Ensembl ID		ENSG00000164841	ENSG00000114902
Uniprot IDs		A0A024R9D4 Q96NL1	Q9Y6A9
PDB IDs
Enriched GO Terms of Interacting Partners?
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