GIT1 and PTPRZ1

Number of citations of the paper that reports this interaction (PubMedID 11381105)
36

Data Source:
HPRD (in vivo, two hybrid)

		GIT1	PTPRZ1
Description		GIT ArfGAP 1	protein tyrosine phosphatase receptor type Z1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Centrosome Cytosol Focal Adhesion Postsynaptic Density Membrane Lamellipodium Calyx Of Held Mitotic Spindle Pole Postsynapse	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Plasma Membrane Synapse Perineuronal Net
	Molecular Function	GTPase Activator Activity Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding
	Biological Process	Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Catalytic Activity Motor Learning Cellular Response To Lipopolysaccharide Positive Regulation Of Microtubule Nucleation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Axonogenesis Central Nervous System Development Learning Or Memory Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs	Signaling by ALK Other interleukin signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)
Interacting Genes		54 interacting genes: ARHGEF6 ARHGEF7 B9D1 BARD1 C8orf33 CCDC113 CDC42 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	16 interacting genes: AASS ADD2 ALK ARHGAP35 BMP1 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B NMB PTN PTPRF TNR
Entrez ID		28964	5803
HPRD ID		06577	01481
Ensembl ID		ENSG00000108262	ENSG00000106278
Uniprot IDs		Q59FC3 Q9Y2X7	B4DFE7 P23471
PDB IDs			3JXF 3S97 5AWX 5H08
Enriched GO Terms of Interacting Partners?
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