GIT1 and KIF1A

Number of citations of the paper that reports this interaction (PubMedID 12522103)
81

Data Source:
HPRD (in vivo)

		GIT1	KIF1A
Description		GIT ArfGAP 1	kinesin family member 1A
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Centrosome Cytosol Focal Adhesion Postsynaptic Density Membrane Lamellipodium Calyx Of Held Mitotic Spindle Pole Postsynapse	Cytosol Kinesin Complex Microtubule Synaptic Vesicle Axon Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extrinsic Component Of Neuronal Dense Core Vesicle Membrane Postsynapse Neuronal Dense Core Vesicle Axon Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding	Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Catalytic Activity Motor Learning Cellular Response To Lipopolysaccharide Positive Regulation Of Microtubule Nucleation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis	Microtubule-based Movement Anterograde Axonal Transport Vesicle-mediated Transport Interkinetic Nuclear Migration Cytoskeleton-dependent Intracellular Transport Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Protein Transport Along Microtubule Dense Core Granule Cytoskeletal Transport Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs			Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Response to placebo treatment in childhood asthma (FVC change) ( 31557306)
Interacting Genes		54 interacting genes: ARHGEF6 ARHGEF7 B9D1 BARD1 C8orf33 CCDC113 CDC42 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	27 interacting genes: ADAMTSL4 AR ESR1 FXR2 GIT1 ICAM1 MDFI MED1 MID2 MKRN3 MTUS2 NOTCH2NLA PLSCR1 PPARG PSMA3 RBPMS RFX6 RGS20 RNF31 RXRA SP1 SPRY2 TNS2 TRAF1 TRIM27 TRIP6 TSPOAP1
Entrez ID		28964	547
HPRD ID		06577	03156
Ensembl ID		ENSG00000108262	ENSG00000130294
Uniprot IDs		Q59FC3 Q9Y2X7	A0A3B3IT28 A0A3B3ITE5 A0A3B3IU40 Q12756
PDB IDs			4EGX 4EJQ 4UXO 4UXP 4UXR 4UXS
Enriched GO Terms of Interacting Partners?
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