GRB10 and FARS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GRB10	FARS2
Description		growth factor receptor bound protein 10	phenylalanyl-tRNA synthetase 2, mitochondrial
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Insulin Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity	TRNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	Insulin Receptor Signaling Pathway Gene Expression Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphorylation Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of Cold-induced Thermogenesis Vascular Associated Smooth Muscle Cell Migration	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation TRNA Processing
Pathways		Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling FLT3 Signaling Response of EIF2AK1 (HRI) to heme deficiency	Mitochondrial tRNA aminoacylation
Drugs			Phenylalanine
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23512250) Area under the curve of insulin levels ( 24699409) Birth weight ( 31043758) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Corpus callosum mid-anterior volume ( 31530798) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Diastolic blood pressure ( 30224653) Eosinophil counts ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) Fasting insulin ( 34059833) Femoral neck bone mineral density ( 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Incremental insulin ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia (treatment resistant) ( 25223841) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 21779181) Total body bone mineral density ( 29304378) Waist circumference adjusted for body mass index ( 34021172)	Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Copper levels ( 26025379) Height ( 28552196) JT interval (sulfonylurea treatment interaction) ( 27958378) Metabolite levels ( 23823483) Obesity (early onset extreme) ( 23563609) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
Interacting Genes		48 interacting genes: AANAT ABL1 AKT1 APP BAIAP2 BCR BLK CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 ERBB2 ERBB4 FARS2 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KANK2 KDR KIT KPNA3 MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NFKBID NOA1 PDGFRB PICK1 RAF1 RET SRC TEKT4 TEPSIN TNK1 TRIM55 TRIM63 TXK ZDHHC17 ZMYND19	69 interacting genes: ADAMTSL4 AGTRAP AJUBA AP1B1 APPL1 BACH2 BAG4 BANP BEX5 CALCOCO2 CBY2 CCDC152 CDCA4 CMTM5 CYSRT1 DGAT2L6 DPH2 DVL3 FHL5 FKBP7 FSD2 GRB10 HIGD1C HMBOX1 HOMEZ IKZF3 ISY1-RAB43 KCNF1 KCTD17 KRT13 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-3 MAN1C1 MDFI MESD MID2 MKRN3 MORN3 NFKBID NOTCH2NLA PCSK5 PPP1R16B RCBTB2 RIMBP3C SPRY1 STX11 SYP TADA2A TEPSIN TFCP2 TPM2 TRAF2 TRIM27 TRIM54 TRIP6 YIF1A ZNF438 ZNF500 ZNF526 ZNF655 ZRANB1
Entrez ID		2887	10667
HPRD ID		03312	09946
Ensembl ID		ENSG00000106070	ENSG00000145982
Uniprot IDs		Q13322	O95363
PDB IDs		1NRV 3HK0	3CMQ 3HFV 3TEG 3TUP 5MGH 5MGU 5MGV 5MGW
Enriched GO Terms of Interacting Partners?
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