GRK5 and AVPR1B

Number of citations of the paper that reports this interaction (PubMedID 10858434)
15

Data Source:
HPRD (in vitro, in vivo)

		GRK5	AVPR1B
Description		G protein-coupled receptor kinase 5	arginine vasopressin receptor 1B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Membrane	Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Beta-adrenergic Receptor Kinase Activity	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding Peptide Binding
	Biological Process	Protein Phosphorylation Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Cell Cycle	Regulation Of Systemic Arterial Blood Pressure By Vasopressin G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Phospholipase A2 Activity Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Viral Entry Into Host Cell Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Arachidonic Acid Secretion Transport Across Blood-brain Barrier
Pathways		G alpha (q) signalling events G alpha (s) signalling events	Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Drugs			Desmopressin Vasopressin Terlipressin PH-284 SR 121463 Atosiban Lypressin
Diseases
GWAS		Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 30060048) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Thymus and reactivation regulated chemokine levels ( 33227023) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31420334 31676865) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	2 interacting genes: AVP GRK5
Entrez ID		2869	553
HPRD ID		02926	02600
Ensembl ID		ENSG00000198873	ENSG00000198049
Uniprot IDs		P34947	P47901
PDB IDs		4TNB 4TND 6PJX
Enriched GO Terms of Interacting Partners?
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