GRK4 and BDKRB2

Number of citations of the paper that reports this interaction (PubMedID 11517230)
18

Data Source:
HPRD (in vitro, in vivo)

		GRK4	BDKRB2
Description		G protein-coupled receptor kinase 4	bradykinin receptor B2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Cortex Dendrite Neuronal Cell Body Photoreceptor Disc Membrane	Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	G Protein-coupled Receptor Internalization Protein Phosphorylation Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Rhodopsin Mediated Signaling Pathway Receptor Internalization	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Anatibant Icatibant Labradimil
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Mean platelet volume ( 32888494) Myocardial infarction ( 33532862) Smoking behaviour (cigarettes smoked per day) ( 30617275)	Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		7 interacting genes: ADRB2 BDKRB2 CALM1 FGFR3 FSHR IKBKG NEDD4	33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4
Entrez ID		2868	624
HPRD ID		00656	00213
Ensembl ID		ENSG00000125388	ENSG00000168398
Uniprot IDs		P32298	P30411
PDB IDs		4YHJ
Enriched GO Terms of Interacting Partners?
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