GRK4 and FGFR3

		GRK4	FGFR3
Description		G protein-coupled receptor kinase 4	fibroblast growth factor receptor 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Cortex Dendrite Neuronal Cell Body Photoreceptor Disc Membrane	Extracellular Region Nucleus Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Transport Vesicle Receptor Complex
	Molecular Function	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Internalization Protein Phosphorylation Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Rhodopsin Mediated Signaling Pathway Receptor Internalization	MAPK Cascade Skeletal System Development Endochondral Ossification Chondrocyte Differentiation Endochondral Bone Growth Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Kinase Activity Chondrocyte Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Negative Regulation Of Developmental Growth Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways			Signaling by activated point mutants of FGFR3 FGFR3 mutant receptor activation t(4;14) translocations of FGFR3 Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer
Drugs			XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Fostamatinib Erdafitinib Pemigatinib Selpercatinib
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Mean platelet volume ( 32888494) Myocardial infarction ( 33532862) Smoking behaviour (cigarettes smoked per day) ( 30617275)	Bladder cancer ( 24163127 20972438) Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Urinary bladder cancer ( 20348956)
Interacting Genes		7 interacting genes: ADRB2 BDKRB2 CALM1 FGFR3 FSHR IKBKG NEDD4	49 interacting genes: ADD1 ANOS1 ARAP1 ATF3 BORA C6orf47 CCDC17 CEP126 CHGB CTSK EPHA4 ERBB2 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GMPS GPSM3 GRB2 GRK4 GTF3C1 HBZ HNRNPL IDUA IRF2BPL KRT8 NDUFS6 NECTIN1 POLA2 PTK2B RADIL RNF130 RPL8 RPS6KA3 SH2B1 SLC25A6 SMG7 SRPK2 STAT1 STAT3 STK32B
Entrez ID		2868	2261
HPRD ID		00656	00624
Ensembl ID		ENSG00000125388	ENSG00000068078
Uniprot IDs		P32298	P22607 Q0IJ44
PDB IDs		4YHJ	1RY7 2LZL 4K33 6LVM 6PNX 7DHL
Enriched GO Terms of Interacting Partners?
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