POLM and UBE2C

Number of citations of the paper that reports this interaction (PubMedID 17588522)
65

Data Source:
BioGRID (enzymatic study)

		POLM	UBE2C
Description		DNA polymerase mu	ubiquitin conjugating enzyme E2 C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Biosynthetic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Exit From Mitosis Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Nonhomologous End-Joining (NHEJ)	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Height ( 31562340)
Interacting Genes		14 interacting genes: CEP55 CTAG1A CTAG1B IKZF3 OGT PCNA PNMA1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H USHBP1	25 interacting genes: ANAPC11 ANAPC2 AURKA CDC20 CKAP2 CXCR1 DTX1 ENO2 ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 RAG1 RELA RNF31 TNNC1 TRIM21 TRIM28 TRIM29 UBA1 UBASH3B UBE3D
Entrez ID		27434	11065
HPRD ID		16208	05717
Ensembl ID		ENSG00000122678	ENSG00000175063
Uniprot IDs		Q9NP87	A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3
PDB IDs		2DUN 2HTF 4LZD 4LZG 4M04 4M0A 4YCX 4YD1 4YD2 5TWP 5TWQ 5TWR 5TWS 5TXX 5TXZ 5TYB 5TYC 5TYD 5TYE 5TYF 5TYG 5TYU 5TYV 5TYW 5TYX 5TYY 5TYZ 5VZ7 5VZ8 5VZ9 5VZA 5VZB 5VZC 5VZD 5VZE 5VZF 5VZG 5VZH 5VZI 5W4F 5ZLC 6AEC 6AEH 6AK5 6AK6 6AK8 6AK9 6AKH 6IPD 6IPE 6IPF 6IPG 6IPH 6IPI 6IPJ 6IPK 6IPL 6IPM 6IPN 6P1M 6P1N 6P1O 6P1P 6P1Q 6P1R 6P1S 6P1T 6P1U 6P1V 6P1W 6WIC 6WID 6WIE	1I7K 4YII 5A31 5KHR 5L9U
Enriched GO Terms of Interacting Partners?
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