SGSM3 and RAB5C

Number of citations of the paper that reports this interaction (PubMedID 26496610)
430

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SGSM3	RAB5C
Description		small G protein signaling modulator 3	RAB5C, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Gap Junction	Lysosomal Membrane Endosome Early Endosome Lipid Droplet Plasma Membrane Endomembrane System Endocytic Vesicle Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Intracellular Protein Transport Cell Cycle Regulation Of Rab Protein Signal Transduction Rap Protein Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Protein Catabolic Process Plasma Membrane To Endosome Transport Activation Of GTPase Activity Regulation Of Cilium Assembly	Intracellular Protein Transport Endocytosis Regulation Of Endocytosis Plasma Membrane To Endosome Transport
Pathways			Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Body mass index ( 26426971) Breast size ( 29855537) Chronotype ( 27494321) Height ( 19570815) Mammographic density (dense area) ( 25342443) Morning vs. evening chronotype ( 27494321) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889)	Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Mean corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: CHRM3 FMO3 GJA1 NF2 RAB39B RAB5A RAB5B RAB5C RPL35	21 interacting genes: ALS2CL APP APPL2 CCR10 DGKI EEA1 ERBB2 GLP1R HOXB13 HRAS INCA1 KRT15 RABAC1 RAPGEFL1 RBSN RIN2 RIN3 SGSM3 SLC27A2 TBC1D15 TBC1D17
Entrez ID		27352	5878
HPRD ID		15285	04947
Ensembl ID		ENSG00000100359	ENSG00000108774
Uniprot IDs		B4DVE3 B9A6J5 Q96HU1	A0A024R1U4 P51148
PDB IDs			4KYI
Enriched GO Terms of Interacting Partners?
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