KLHL20 and ARHGEF12

Number of citations of the paper that reports this interaction (PubMedID 21670212)
20

Data Source:
BioGRID (enzymatic study)

		KLHL20	ARHGEF12
Description		kelch like family member 20	Rho guanine nucleotide exchange factor 12
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle
Drugs
Diseases
GWAS		Feeling miserable ( 29500382)	Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778 30104761) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Height ( 31562340) Intraocular pressure ( 29617998 25637523 31798171 29785010 31959993 30054594 28073927 29235454) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		42 interacting genes: ACTA1 ARHGEF12 ATG9A BCL6 BEX1 BEX2 BRINP2 C1orf216 C20orf85 C21orf58 CEP126 CIDEC CLCNKA COL8A1 CORO7 CRK CRMP1 DUSP21 ECT2 ENKD1 EPAS1 ERG28 GBP2 HR IVNS1ABP KLHL38 LRIF1 LUC7L2 MTNR1A NEDD9 NTAQ1 PIN1 PML PRMT6 RANBP3 RECK SLC13A5 STK16 SUV39H1 TFAP2D TNPO2 USP20	18 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC VPS26C
Entrez ID		27252	23365
HPRD ID		13918	09207
Ensembl ID		ENSG00000076321	ENSG00000196914
Uniprot IDs		Q9Y2M5	B4E2K6 E9PMR6 Q9NZN5
PDB IDs		5YQ4 6GY5	1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?
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