RNF115 and RAB7A

Number of citations of the paper that reports this interaction (PubMedID 12972561)
37

Data Source:
HPRD (in vitro, in vivo)

		RNF115	RAB7A
Description		ring finger protein 115	RAB7A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding
	Biological Process	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)	Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		35 interacting genes: AKT1 APP ATN1 CD160 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MAVS MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A STING1 TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2	35 interacting genes: CHM COPG1 ENOPH1 FABP6 GP9 H1-10 KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 RPN1 SLC2A4 SNX3 TMCC1 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41 ZHX2
Entrez ID		27246	7879
HPRD ID		18328	03805
Ensembl ID		ENSG00000265491	ENSG00000075785
Uniprot IDs		Q9Y4L5	A0A158RFU6 P51149
PDB IDs			1T91 1YHN 3LAW 6IYB 6WCW
Enriched GO Terms of Interacting Partners?
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