PPA2 and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
9

Data Source:
BioGRID (two hybrid)

		PPA2	VKORC1
Description		inorganic pyrophosphatase 2	vitamin K epoxide reductase complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Inorganic Diphosphatase Activity Protein Serine/threonine Phosphatase Activity	Protein Binding Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Mitochondrial Membrane Potential Diphosphate Metabolic Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Bone Development
Pathways		Mitochondrial tRNA aminoacylation Pyrophosphate hydrolysis	Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Number of sexual partners ( 30643258) Regular attendance at a religious group ( 29970889) Response to antipsychotic treatment ( 23241943) Risk-taking tendency (4-domain principal component model) ( 30643258)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		3 interacting genes: LARP7 TRIM63 VKORC1	94 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DCTPP1 DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL METTL7B MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		27068	79001
HPRD ID		18494	10540
Ensembl ID		ENSG00000138777	ENSG00000167397
Uniprot IDs		Q9H2U2	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs			6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?
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