PPA2 and LARP7

		PPA2	LARP7
Description		inorganic pyrophosphatase 2	La ribonucleoprotein 7, transcriptional regulator
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Nucleus Nucleoplasm Cytosol 7SK SnRNP Ribonucleoprotein Complex
	Molecular Function	Magnesium Ion Binding Inorganic Diphosphatase Activity Protein Serine/threonine Phosphatase Activity	RNA Binding Protein Binding U6 SnRNA Binding 7SK SnRNA Binding
	Biological Process	Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Mitochondrial Membrane Potential Diphosphate Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Box C/D RNA 3'-end Processing MRNA Processing Spermatogenesis RNA Splicing Cell Differentiation Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II U6 2'-O-snRNA Methylation
Pathways		Mitochondrial tRNA aminoacylation Pyrophosphate hydrolysis
Drugs
Diseases
GWAS		Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Number of sexual partners ( 30643258) Regular attendance at a religious group ( 29970889) Response to antipsychotic treatment ( 23241943) Risk-taking tendency (4-domain principal component model) ( 30643258)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Dental caries (decayed and filled deciduous teeth) ( 31533690) Meat-related diet ( 32066663) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: LARP7 TRIM63 VKORC1	89 interacting genes: APP BARD1 BRCA1 CHRNB4 GABRG2 GAR1 JMJD6 LRRK2 MCUB MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OSTC PAPSS1 PPA2 PRPF40A PUF60 RN7SK RRH SMS ZGRF1
Entrez ID		27068	51574
HPRD ID		18494	17095
Ensembl ID		ENSG00000138777	ENSG00000174720
Uniprot IDs		Q9H2U2	Q4G0J3
PDB IDs			4WKR 5KNW 6D12
Enriched GO Terms of Interacting Partners?
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