LAT and GJA8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LAT	GJA8
Description		linker for activation of T cells	gap junction protein alpha 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Membrane Raft	Plasma Membrane Integral Component Of Plasma Membrane Connexin Complex
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity	Gap Junction Channel Activity Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity Regulation Of T Cell Activation	Lens Development In Camera-type Eye Cell-cell Signaling Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules	Gap junction assembly
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Retinopathy x type 2 diabetes interaction ( 32541925) Triglyceride levels ( 34074324)
Interacting Genes		95 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MFSD14B MFSD5 MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35C2 SLC51B SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2	121 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 YIF1A YIPF6
Entrez ID		27040	2703
HPRD ID		03832	02939
Ensembl ID		ENSG00000213658	ENSG00000121634
Uniprot IDs		A0A024QZD6 O43561	P48165 X5D7G1
PDB IDs
Enriched GO Terms of Interacting Partners?
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