GJA8 and MGST2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GJA8	MGST2
Description		gap junction protein alpha 8	microsomal glutathione S-transferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Connexin Complex	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Gap Junction Channel Activity Protein Binding Identical Protein Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Identical Protein Binding Glutathione Binding
	Biological Process	Lens Development In Camera-type Eye Cell-cell Signaling Transmembrane Transport Gap Junction-mediated Intercellular Transport	Lipid Metabolic Process Glutathione Biosynthetic Process Response To Organonitrogen Compound Leukotriene Biosynthetic Process Response To Lipopolysaccharide Membrane Lipid Catabolic Process Positive Regulation Of Inflammatory Response Regulation Of Catalytic Activity Cellular Oxidant Detoxification
Pathways		Gap junction assembly	Glutathione conjugation Aflatoxin activation and detoxification
Drugs			Glutathione
Diseases
GWAS		Retinopathy x type 2 diabetes interaction ( 32541925) Triglyceride levels ( 34074324)	Metabolite levels ( 23823483)
Interacting Genes		121 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 YIF1A YIPF6	23 interacting genes: ASIC1 BCL2L10 BCL2L2 C3orf52 CCL3L3 CLEC14A CREB3 CREB3L1 CTXN3 DNAJC30 GIMAP5 GJA8 GPX8 HDHD2 PLN PNKP SEC22A SEC22B SGCB STX8 TMEM167B TMEM207 VAMP3
Entrez ID		2703	4258
HPRD ID		02939	03436
Ensembl ID		ENSG00000121634	ENSG00000085871
Uniprot IDs		P48165 X5D7G1	Q99735
PDB IDs			6SSR 6SSS 6SSU 6SSW
Enriched GO Terms of Interacting Partners?
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