BEX3 and SMPD1

Number of citations of the paper that reports this interaction (PubMedID 11238738)
13

Data Source:
HPRD (in vivo)

		BEX3	SMPD1
Description		brain expressed X-linked 3	sphingomyelin phosphodiesterase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Space Lysosome Endosome Lipid Droplet Plasma Membrane Endolysosome Lamellar Body Lysosomal Lumen Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Multicellular Organism Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Plasma Membrane Repair Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Response To Xenobiotic Stimulus Response To Virus Response To Ionizing Radiation Termination Of Signal Transduction Response To Type I Interferon Response To Tumor Necrosis Factor Cellular Response To UV Positive Regulation Of Protein Dephosphorylation Wound Healing Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Endocytosis Ceramide Biosynthetic Process Viral Entry Into Host Cell Response To Interleukin-1 Cellular Response To Calcium Ion
Pathways		NADE modulates death signalling	Glycosphingolipid metabolism
Drugs			Amlodipine Chlorpromazine Desipramine Medical Cannabis
Diseases
GWAS			Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Malaria ( 31844061) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		42 interacting genes: AIMP2 AKAP8L BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO EMILIN1 ENKD1 FSD2 GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417	6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2
Entrez ID		27018	6609
HPRD ID		02291	06353
Ensembl ID		ENSG00000166681	ENSG00000166311
Uniprot IDs		Q00994	E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0
PDB IDs		1SA6	5I81 5I85 5I8R 5JG8
Enriched GO Terms of Interacting Partners?
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